Genome-wide pleiotropy of osteoporosis-related phenotypes: The framingham study
نویسندگان
چکیده
منابع مشابه
Genome-Wide Pleiotropy of Osteoporosis-Related Phenotypes: The Framingham Study
Genome-wide association studies offer an unbiased approach to identify new candidate genes for osteoporosis. We examined the Affymetrix 500K + 50K SNP GeneChip marker sets for associations with multiple osteoporosis-related traits at various skeletal sites, including bone mineral density (BMD, hip and spine), heel ultrasound, and hip geometric indices in the Framingham Osteoporosis Study. We ev...
متن کاملGenome-wide association study for empirically derived metabolic phenotypes in the Framingham Heart Study offspring cohort
We used data reduction and clustering methods to identify five phenotypically homogeneous groups of study participants with similar profiles for cardiovascular disease risk factors. We constructed both qualitative (binary subgroup membership) and quantitative traits (probability of subgroup membership) for each individual. The Cluster 1 comprised individuals who were generally healthy and had s...
متن کاملRegion-based analysis in genome-wide association study of Framingham Heart Study blood lipid phenotypes
Due to the high-dimensionality of single-nucleotide polymorphism (SNP) data, region-based methods are an attractive approach to the identification of genetic variation associated with a certain phenotype. A common approach to defining regions is to identify the most significant SNPs from a single-SNP association analysis, and then use a gene database to obtain a list of genes proximal to the id...
متن کاملGenome-wide association analysis of cardiovascular-related quantitative traits in the Framingham Heart Study
Multivariate linear growth curves were used to model high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and systolic blood pressure (SBP) measured during four exams from 1659 independent individuals from the Framingham Heart Study. The slopes and intercepts from each of two phenotype models were tested for association with 348,053 autosomal single-nucleotide poly...
متن کاملThe Framingham Heart Study 100 K SNP Genome - Wide
Background: The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected phenotypes have substantial genetic contributors; yet most genetic determinants remain to be identified. Using single nucleotide polymorphisms (SNPs) from a 100K genome-wide sc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2010
ISSN: 0884-0431,1523-4681
DOI: 10.1002/jbmr.38